Our Research
Our lab studies anticancer (brain tumors) drug therapy by employing systems-based approaches that incorporate in silico methods, experimental measurements and mathematical modeling. We develop physiologically-based pharmacokinetic (PBPK) and pharmacodynamic (PD) models, sometimes referred to as quantitative systems pharmacology (QSP) models. There is a desire to build mechanistic models related to drug action and disease biology. We piloted the idea of cell type-specific (CTS) PK/PD models that may differentiate drug actions in specific cell types or clonal populations. Ultimately, model predictions are used to design novel drug therapy and achieve precision therapeutics.
EDUCATION
RESEARCH INTERESTS
Brain Tumor Drug Therapy
Single-Cell Pharmacodynamic Models
Hybrid Stochastic-Mechanistic Models
University of Wisconsin
Massachusetts College of Pharmacy, BS Pharmacy
University of Florida, PharmD
University of Arizona, PhD
Post-Graduate Education - Sabbaticals
Northwestern University, Neuro-Oncology
University of Washington, BioMedical Engineering