Our Research

Our lab studies anticancer (brain tumors) drug therapy by employing systems-based approaches that incorporate in silico methods, experimental measurements and mathematical modeling. We develop physiologically-based pharmacokinetic (PBPK) and pharmacodynamic (PD) models, sometimes referred to as quantitative systems pharmacology (QSP) models. There is a desire to build mechanistic models related to drug action and disease biology. We piloted the idea of cell type-specific (CTS) PK/PD models that may differentiate drug actions in specific cell types or clonal populations.  Ultimately, model predictions are used to design novel drug therapy and achieve precision therapeutics.

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Brain Tumor Drug Therapy

Single-Cell Pharmacodynamic Models

Hybrid Stochastic-Mechanistic Models

University of Wisconsin

Massachusetts College of Pharmacy, BS Pharmacy

University of Florida, PharmD

University of Arizona, PhD

Post-Graduate Education - Sabbaticals

Northwestern University, Neuro-Oncology

University of Washington, BioMedical Engineering